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New Anti-Bacterial Coating to Prevent Infection of Joint Prosthesis




Joint prosthesis and orthopaedic implants may get colonized by bacteria during surgery.


Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.


Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.


An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.


Antibacterial coatings classification


DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 


Antibacterial coating of joint prosthesis: results of a multi-center clinical trial


More publications and Clinical Data

Operative Procedure (VIDEO)


Clinical Orthopaedics and Related Research (CORR)

International Orthopaedics

Muskuloskeletal Infection Society (MSIS)


The Galeazzi Institute in Milano is among the leaders of a European Project, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs. To learn more, visit the official website of the IDAC Project and Galeazzi.




First Presented at the International Meeting on Biofilm-Related Infections in Orthopedic and Trauma Surgery.

Milano, Italy, Dec. 12-14, 2013.

 Visit also: 

Milano Biofilm Meeting 2015


Milano Biofilm Meeting, 23-24 June, 2017



Bioglass: a New Anti-Bacterial Bone Substitute to Treat Osteomyelitis


Treatment of osteomyelitis often requires surgical debridement and removal of all necrotic and infection bone and surrounding tissues.


This procedure may lead to significant bone loss, that increase the bone defect already present and due to the septic process in itself.


Treatment of bone defects in infections may be extremely difficult and challenging.


Recently, a new biomaterial has been made available, that not only allows to fill the bone defect and facilitate bone healing, but also provides a direct anti-bacterial effect, due to its chemical and physical properties.


This "bioglass" has been tested in a long series of patients and provided excellent results both in clearinng infection and in restoring bone defect.


To learn more



CDT App to Help Diagnose Prosthetic Infection


Diagnosis of peri-prosthetic infection can be difficult.


A new App, downloadable on smartphones can make it easier...


Lean how ! 




SINOVIASURE: the new rapid test to diagnose a peri-prosthetic infection !


Read more... 

NEW DIAGNOSTIC TOOLS ... - Bone and Joint Infections

DTT: a New Method to Isolate Bacteria

DTT: a New Method to Isolate Bacteria - Bone and Joint Infections

Diagnosis of prosthetic joint infections (PJIs) remains a challenge for microbiologists, despite new techniques for bacteria isolation have been developed in recent years.


A widely recognized standard method has not yet been indicated mainly because of limitations due difficult procedures and need of dedicated instrumentation.


Dithiothreitol (DTT) has been recently shown to be able to dislodge bacteria from biofilm, keeping them alive and cultivable for identification and antibiotic susceptibility testing.


DTT may be helpful for PJIs diagnosis, thanks to its ease of use and its high sensitivity and specificity.


To learn more, visit www.microdttect.com or click here

Cerament G - New Treatment for Bone Defects in Osteomyelitis


Osteoconductive Bone Substitute with Gentamicin:

The Filler for Bone Defects in Infections.


Video: The Oxford (UK) experience


Read more ...! 


Bone and Joint Infections

Galeazzi Institute - Milano - Italy

Bone and Joint Infections


Bone and Joint Infections

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